Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.

作者：Huang, Sheng Zhuo; Zhang, Xing Jie; Li, Xing Yao; Kong, Ling Mei; Jiang, He Zhong; Ma, Qing Yun; Liu, Yu Qing; Hu, Jiang Miao; Zheng, Yong Tang; Li, Yan; Zhou, Jun^*; Zhao, You Xing

来源：Phytochemistry, 2012, 75: 99-107.

DOI：10.1016/j.phytochem.2011.11.013

• Daphne acutiloba
• Thymelaeaceae
• Daphnane
• Diterpene ester
• Cytotoxicity
• Anti-HIV-1

Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in.13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC50 below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC50 0.17 nM and SI 187,010.

• 出版日期2012-3
• 单位中国科学院; 中国热带农业科学院; 中国科学院昆明植物研究所; 中国科学院昆明动物研究所