Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion

作者：Lee Hyun Ju; Lee Se Guen; Oh Eun Jung; Chung Ho Yun; Han Sang Ik; Kim Eun Jung; Seo Song Yi; Do Ghim Han; Yeum Jeong Hyun; Choi Jin Hyun^*

来源：Colloids and Surfaces B: Biointerfaces , 2011, 88(1): 505-511.

DOI：10.1016/j.colsurfb.2011.07.041

• Silver nanoparticles
• Stability
• Antimicrobial activity
• Polyethyleneimine
• Sodium borohydride
• Cytotoxicity

Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH(4)) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH(4). PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.

• 出版日期2011-11-1