Molecular Diversity of Three-Component Reactions of N-Benzylbenzimidazolium Salts, Isatin, and Malononitrile or Ethyl Cyanoacetate

作者：Hui, Li; Li, Hong-Yan; Yan, Chao-Guo^*

来源：European Journal of Organic Chemistry, 2012, 2012(16): 3157-3164.

DOI：10.1002/ejoc.201200269

• Multicomponent reactions
• Zwitterions
• Nitrogen heterocycles
• Molecular diversity

The three-component reactions of N-benzylbenzimidazolium salts, isatins, and malononitrile or ethyl cyanoacetate showed very interesting molecular diversity depending on the structures of the benzimidazolium salts. The reactions of N-benzyl-N'-p-nitrobenzylbenzimidazolium salts gave a series of zwitterionic salts in good yields. Under similar reaction conditions the reactions of N-benzyl-N'-phenacylbenzimidazolium salts resulted in the unexpected products with opening of the imidazole ring.

• 出版日期2012-6
• 单位扬州大学