Diversity in Renal Function Monitoring and Dose Modifications During Treatment for Childhood Cancer: A Call for Standardization

作者：Blufpand Hester N^*; Hes Nicole; Bokenkamp Arend; van de Wetering Marianne D; Kaspers Gertjan J L

来源：Pediatric Blood and Cancer, 2014, 61(2): 337-344.

DOI：10.1002/pbc.24572

• adverse effects
• chemotherapy induced nephrotoxicity
• childhood cancer
• dose modifications in case of renal dysfunction
• renal function

Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337-344.

• 出版日期2014-2