Accretion of Fat-Free Mass Rather Than Fat Mass in Infancy Is Positively Associated with Linear Growth in Childhood

作者：Admassu Bitiya^*; Ritz Christian; Wells Jonathan C K; Girma Tsinuel; Andersen Gregers S; Belachew Tefera; Owino Victor; Michaelsen Kim F; Abera Mubarek; Wibaek Rasmus; Friis Henrik; Kaestel Pernille

来源：Journal of Nutrition, 2018, 148(4): 607-615.

DOI：10.1093/jn/nxy003

• fat-free mass
• fat mass
• body composition
• linear growth
• height
• length
• children

Background: We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied.
Objective: This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children.
Methods: In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured <= 6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD.
Results: FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (beta = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (beta = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (beta = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model.
Conclusions: In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.

• 出版日期2018-4