Anti-HIV and antiplasmodial activity of original flavonoid derivatives

作者：Casano Gilles; Dumetre Aurelien; Pannecouque Christophe; Hutter Sebastien; Azas Nadine^*; Robin Maxime

来源：Bioorganic & Medicinal Chemistry, 2010, 18(16): 6012-6023.

DOI：10.1016/j.bmc.2010.06.067

• Flavonoid
• Chalcone
• Plasmodium falciparum
• HIV-1
• HIV-2
• Selectivity index

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial activity than flavonoids. Methoxyflavone 7e was the only one compound active in both P. falciparum and HIV-1 whereas aminomethoxyflavones showed activity against HIV-2. Para substitution on the B ring seemed to increase HIV-2 potency.

• 出版日期2010-8-15
• 单位河北医科大学