Development of a miniature mass spectrometer with in-source desolvation

作者：Xue, Zhenhua; Chen, Yan; He, Muyi; Xiong, Xingchuang; Fang, Xiang; Zhao, Yonggang; Xu, Wei^*

来源：International Journal of Mass Spectrometry, 2016, 397: 1-5.

DOI：10.1016/j.ijms.2015.12.008

• Miniature mass spectrometer
• In-source fragmentation
• Desolvation
• In-source desolvation

Miniature mass spectrometers could meet the on-site chemical analysis requirements in applications such as space exploration, homeland security, etc. However, miniaturization of a mass spectrometer would sacrifice its performance due to simplified instrumentation and limitations on power and size. In this study, in-source desolvation capability was developed for a miniature mass spectrometer. Similar to the conventional in-source fragmentation technique, the in-source desolvation is more gentle, which is designed to fragment clusters and droplets other than ions. In-source desolvation could effectively help the desolvation of droplets generated by electrospray ionization, and both signal intensity and signal-to-noise ratio of a mass peak could be increased. As a result, sensitivity improvement could be achieved for the miniature mass spectrometer. Compared to the desolvation techniques used on a lab-scale instrument (heated interface, desolvation gas, for instance), the in-source desolvation method is more suitable and economic for a miniature mass spectrometer.

• 出版日期2016-3-15
• 单位北京理工大学; 中国原子能科学研究院; 中国计量科学研究院