Acute-phase proteins and incidence of diabetes: a population-based cohort study

作者：Muhammad Iram Faqir; Borne Yan; Hedblad Bo; Nilsson Peter M; Persson Margaretha; Engstrom Gunnar^*

来源：Acta Diabetologica, 2016, 53(6): 981-989.

DOI：10.1007/s00592-016-0903-8

• Acute-phase proteins
• Diabetes
• Incidence
• Ceruloplasmin
• Alpha-1-antitrypsin
• Orosomucoid
• Haptoglobin
• CRP

Aims To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmo "Diet and Cancer Study-Cardiovascular Cohort (MDCS-CC).
Methods The study population consists of 4246 participants (aged 46-67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins.
Results During a mean follow-up period of 15.6 +/- 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83-1.67; p = 0.51), 1.19 (CI: 0.85-1.62; p = 0.10), and 1.40 (CI: 1.01-1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively.
Conclusion The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.

• 出版日期2016-12