Doxorubicin-loaded boron-rich polymer nanoparticles for orthotopically implanted liver tumor treatment

作者：Zhang, Lu-zhong; Zhang, Ya-jun; Wu, Wei^*; Jiang, Xi-qun

来源：Chinese Journal of Polymer Science, 2013, 31(5): 778-786.

DOI：10.1007/s10118-013-1267-y

• Dextran-PAPBA nanoparticles
• DOX
• Drug delivery
• Antitumor

The in vivo behaviors of doxorubicin (DOX)-loaded dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) were studied. The DOX-loaded NPs had a narrowly distributed diameter of ca. 74 nm and mainly accumulated in liver of tumor-bearing mice after intravenous injection as demonstrated by in vivo real-time near infrared fluorescent imaging. The DOX contents in various tissues were quantified and consisted well with the results of fluorescent imaging. The biodistribution pattern of DOX-loaded NPs encourages us to investigate their liver tumor treatment by using an orthotopically implanted liver tumor model, revealing that the DOX-loaded NPs formulation had better antitumor effect than free DOX.

• 出版日期2013-5
• 单位南京大学; 南通大学