Unprecedented N(H)-bridged tetraaza[1.1.1.1]m,p,m,p-cyclophanes

作者：Touil Mounia; Raimundo Jean Manuel; Lachkar Mohammed; Marsal Philippe; Siri Olivier^*

来源：Tetrahedron, 2010, 66(24): 4377-4382.

DOI：10.1016/j.tet.2010.03.114

• Macrocycle
• Cyclophane
• Nucleophilic aromatic substitution

The first uncatalyzed preparation of tetraaza[1.1.1.1]m,p,m,p-cyclophanes (symmetrical and unsymmetrical) gave access to previously unknown N(H)-bridged derivatives that could be further substituted. NMR studies and theoretical calculations show that these macrocycles adopt an 1,3-alternated conformation.

• 出版日期2010-6-12