A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and aminoglycosides

作者：Tada Tatsuya; Uechi Kohei; Nakasone Isamu; Miyazato Zenji; Shinzato Takashi; Shimada Kayo; Tsuchiya Mitsuhiro; Kirikae Teruo^*; Fujita Jiro

来源：Journal of Medical Microbiology, 2018, 67(1): 29-32.

DOI：10.1099/jmm.0.000655

• hemin auxotrophic
• Enterobacter cloacae
• resistance to carbapenems
• resistance to aminoglycosides

Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiTyaiV- ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.

• 出版日期2018-1