A novel antibacterial agent based on AgNPs and Fe3O4 loaded chitin microspheres with peroxidase-like activity for synergistic antibacterial activity and wound-healing

作者：Yu, Ningxiang; Cai, Taimei; Sun, Yong; Jiang, Chengjia; Xiong, Hua^*; Li, Yanbin; Peng, Hailong^*

来源：International Journal of Pharmaceutics, 2018, 552(1-2): 277-287.

DOI：10.1016/j.ijpharm.2018.10.002

• AgNPs
• Fe3O4
• Chitin nanofibrous microsphere
• Peroxidase-like activity
• Synergetic antibacterial effect
• Wound healing

In this study, a novel antibacterial agent was developed based on chitin nanofibrous microspheres loaded with AgNPs and Fe3O4 nanoparticles (Ag-Fe3O4-NMs) for synergistic antibacterial activity and wound healing. Ag-Fe3O4-NMs was prepared via an in situ synthetic method which showed an excellent porosity and wettability. Moreover, Ag-Fe3O4-NMs were capable of sustained release of Ag+ and catalysed the decomposition of low H2O2 concentrations to generate hydroxyl radical (center dot OH). The center dot OH and Ag+ showed higher antibacterial activity and inhibited the toxicity with high dose of AgNPs and H2O2. In vitro biocompatibility results suggested that Ag-Fe3O4-NMs have low toxicity and low hemolysis. Thus, a novel antibacterial agent with enhanced synergistic antibacterial activity was obtained by combination of Ag-Fe3O4-NMs and H2O2 at a low and biologlically safe dosage, which could facilitate fibroblast growth, accelerate epithelialization, and promote the healing rate of infected wounds.

• 出版日期2018-12-1
• 单位南昌大学; 食品科学与技术国家重点实验室