A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus

作者：Liu Dong Ze; Wang Fei; Yang Liu Meng; Zheng Yong Tang; Liu Ji Kai^*

来源：Journal of Antibiotics, 2007, 60(5): 332-334.

• Tyromyces chioneus
• culture broth
• cadinane sesquiterpene
• anti-HIV-1

A new cadinane sesquiterpene (4 beta,14-dihydroxy-6 alpha,7 beta H-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50,=3.0 mu g/ml (SI=25.4).

• 出版日期2007-5
• 单位中国科学院大学; 中国科学院昆明植物研究所