科研之友
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摘要
Objective: To investigate the inhibitory effect of iguratimod on the development of coronary arteritis in a murine model of vasculitis induced with a Candida albicans water-soluble fraction (CAWS). Methods: CAWS was intraperitoneally injected to C57BL/ 6 mice for 5 days, followed by administration of iguratimod or PBS. At day 3, day 10 and day 28, the mice were sacrificed. The status of vasculitis in the coronary arteries and the aortic root was investigated histologically, and plasma cytokines and chemokines were measured. Results: CAWS injection induced active inflammation in the aortic root and coronary arteries which were similar to the coronary arteritis in Kawasaki disease (KD). The vasculitis can be reduced by iguratimod at day 3 and this effect persisted for 28 days. The severity of the inflammation of the aortic root and the coronary arteries were reduced in iguratimod group (P< 0.05). The levels of cytokines including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-10, IL-6, tumor necrosis factor-a and matrix metalloproteinase (MMP)-9 were increased in CAWS induced groups, while the level of IL-6 were suppressed dramatically by iguratimod (P< 0.05). Furthermore, there is a strong correlation between the severity of the vasculitis and the plasma interleukin-6 levels. Conclusion: Iguratimod was effective in suppressing CAWS-induced coronary arteritis and expression level of IL-6, which suggests that iguratimod could potentially be an effective therapeutic strategy for arteritis in KD, and serum IL-6 could be a marker for the biological effects of iguratimod in KD.
