Antimicrobial prenylated benzoylphloroglucinol derivatives and xanthones from the leaves of Garcinia goudotiana

作者：Mahamodo Sania; Riviere Celine^*; Neut Christel; Abedini Amin; Ranarivelo Heritiana; Duhal Nathalie; Roumy Vincent; Hennebelle Thierry; Sahpaz Sevser; Lemoine Amelle; Razafimahefa Dorothee; Razanamahefa Bakonirina; Bailleul Francois; Andriamihaja Bakolinirina

来源：Phytochemistry, 2014, 102: 162-168.

DOI：10.1016/j.phytochem.2014.03.006

• Garcinia goudotiana
• Clusiaceae Madagascar
• Benzoylphloroglucinol derivatives
• Xanthones
• Antimicrobial activities
• Cytotoxic activities

Bioassay-guided fractionation using antimicrobial assay of the crude acetonic extract of Garcinia goudotiana leaves and of its five partitions led to the isolation of two new prenylated benzoylphloroglucinol derivatives, goudotianone 1 (1) and goudotianone 2 (2), in addition to two known compounds including one xanthone, 1,3,7-trihydroxy-2-isoprenylxanthone (3), and one triterpenoid, friedelin (4). Their structures were elucidated on the basis of different spectroscopic methods, including extensive 1D- and 2D-NMR spectroscopy and mass spectrometry. The crude acetonic extract, the methylene chloride and ethyl acetate partitions, and some tested compounds isolated from this species (1-3) demonstrated selective significant antimicrobial activities against Gram-positive bacteria, in particular Staphylococcus lugdunensis, Enterococcus faecalis and Mycobacterium smegmatis. The potential cytotoxic activities of these extracts and compounds were evaluated against human colon carcinoma HT29 and human fetal lung fibroblast MRC5 cells.

• 出版日期2014-6