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摘要
Two series of some various N-phenyl/benzothiazolyl acetamide-fused quinazoline derivatives were synthesized and tested for their antimycobacterial activity against M. tuberculosis H37Rv. Moreover, the synthesized analogs were also screened against human PC3 cells in order to explore their anticancer activity. The in vitro antimycobacterial screening revealed that, among the synthesized analogs, N-benzothiazolyl acetamide derivatives showed remarkable antimycobacterial activity. However, the best anticancer results were observed amongst the N-phenyl acetamide-substituted quinazoline derivatives. The newly synthesized compounds were characterized through IR, H-1 NMR, C-13 NMR, MS, and elemental analysis.
- 出版日期2015-7
