Health-related physical fitness in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation

作者：Persoon Saskia; Kersten Marie Jose^*; Buffart Laurien M; Vander Slagmolen Griet; Baars Joke W; Visser Otto; Manenschijn Annelies; Nollet Frans; Chinapaw Mai J M

来源：Journal of Science and Medicine in Sport, 2017, 20(2): 116-122.

DOI：10.1016/j.jsams.2016.01.006

• Exercise tolerance
• Muscle strength
• Body composition
• Hematology

Objectives: We aimed to examine health-related physical fitness and its demographic and clinical correlates in patients recently treated with autologous stem cell transplantation.
Design: Cross-sectional study.
Methods: In 109 patients (multiple myeloma: n = 58, lymphoma: n = 51, median age: 55, range: 19-67 years) maximal exercise testing was conducted to assess cardiorespiratory fitness (VO2peak) Upper and lower extremity muscle strength were assessed with hand grip-and fixed dynamometry and body composition with whole body DXA scans. In addition, we assessed the patients' demographic and clinical characteristics and examined whether they were associated with health-related physical fitness.
Results: VO2peak was 21.7 (5.5) mL/min/kg, 26% below reference values. Muscle strength was also reduced when compared with reference values (upper extremity: 90%, lower extremity: 80%) and 73% of our population was classified as overweight or obese. Being female and being older were significantly associated with a lower cardiorespiratory fitness (gender: beta = -2.7, 95%CI= -4.6:-0.7 mL/min/kg; age: beta= -0.2, 95%CI = -0.3;-0.1 mL/min/kg), upper (gender: beta = -17.7, 95%CI = -20.1;-15.3 kg; age: beta= -0.2, 95%CI = -0.3;-0.1 kg) and lower (gender: beta= -58.3, 95%CI = -73.5:- 43.0 Nm; age: beta= -1.7, 95%CI = -2.4;-1.1 Nm) extremity muscle strength. Patients who were non-smoking (beta= -5.3, 95%CI = -8.7;-1.9), women (beta=7.2, 95%CI=4.8;9.6) and diagnosed with multiple myeloma (beta=4.6, 95%CI = 2.2;6.9) had a higher percentage body fat.
Conclusions: The physical fitness deficits in this population indicate the need for targeted interventions.

• 出版日期2017-2