A convenient synthesis of deuterium labeled tertiary aliphatic nitro ketones and nitriles - starting materials for preparation of deuterated cyclic nitrones, isomeric hydroxylamines, and corresponding C-nitroso compounds

作者：Grela Karol^*; Konopski Leszek

来源：Tetrahedron, 2010, 66(20): 3614-3622.

DOI：10.1016/j.tet.2010.03.022

• Deuterated nitro ketones
• Deuterated nitro nitriles
• Deuterated hydroxylamines
• Deuterated cyclic nitrones
• Deuterated nitroso ketones
• Deuterated nitroso nitriles
• Deuterium labeling

Tertiary aliphatic beta- and gamma-nitro nitriles and ketones deuterated in (several) selected positions had been synthesized. The deuterated nitro compounds served as a starting material for the corresponding deuterium labeled nitrones or hydroxylamines (reducing with aluminum amalgam). Further oxidation of the last two groups of compounds with sodium periodate or m-CPBA afforded the relevant deuterated tertiary C-nitroso compounds.

• 出版日期2010-5-15