CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung

作者：Zelante Teresa^*; Wong Alicia Yoke Wei; Ping Tang Jing; Chen Jinmiao; Sumatoh Hermi R; Vigano Elena; Bing Yu Hong; Lee Bernett; Zolezzi Francesca; Fric Jan; Newell Evan W; Mortellaro Alessandra; Poidinger Michael; Puccetti Paolo; Ricciardi Castagnoli Paola

来源：Cell Reports, 2015, 12(11): 1789-1801.

DOI：10.1016/j.celrep.2015.08.030

Th17 cells express diverse functional programs while retaining their Th17 identity, in some cases exhibiting a stem-cell-like phenotype. Whereas the importance of Th17 cell regulation in autoimmune and infectious diseases is firmly established, the signaling pathways controlling their plasticity are undefined. Using a mouse model of invasive pulmonary aspergillosis, we found that lung CD103(+) dendritic cells (DCs) would produce IL-2, dependent on NFAT signaling, leading to an optimally protective Th17 response. The absence of IL-2 in DCs caused unrestrained production of IL-23 and fatal hyperinflammation, which was characterized by strong Th17 polarization and the emergence of a Th17 stem-cell-like population. Although several cell types may be affected by deficient IL-2 production in DCs, our findings identify the balance between IL-2 and IL-23 productions by lung DCs as an important regulator of the local inflammatory response to infection.

• 出版日期2015-9-22