Activated platelets correlate with mobilization of naive CD34(+) cells and generation of CD34(+)/KDR+ cells in the circulation. A meta-regression analysis

作者：de Boer H C^*; van Oeveren Rietdijk A M; Rotmans J I; Dekkers O M; Rabelink T J; van Zonneveld A J

来源：Journal of Thrombosis and Haemostasis, 2013, 11(8): 1583-1592.

DOI：10.1111/jth.12315

• aspirin
• circulation
• platelets
• stem cells
• vasculature

Background: Bone marrow-derived circulating CD34(+) progenitor cells participate in remodeling and repair of the vasculature. Coexpression of the kinaseinsert domain-containing receptor (KDR) has been proposed to identify the regenerative capacity. Recently, we provided evidence that the major fraction of circulating CD34(+)/KDR+ cells is not mobilized from bone marrow, but is generated at sites of vascular injury through interaction with platelets. Objectives: To determine the relationship between platelet activation, the recruitment of naive CD34(+) cells and the generation of CD34(+)/KDR+ progenitor cells in a broad range of (patho) physiologic conditions, a detailed meta-regression analysis was conducted. Methods/Results: Twenty-eight conditions were found in which the numbers of CD34(+) and/or CD34(+)/KDR+ cells and the levels of soluble P-selectin, as a marker for in vivo platelet activation, were documented. To combine heterogeneous data from 214 selected articles, results were standardized to a uniform scale by calculating standardized mean differences (SMDs) obtained from patient and control cohorts. Subsequently, a random-effects meta-regression analysis was performed on pooled SMDs. Conclusions: Our systemic survey supports a model in which activated platelets are a determinant for mobilization of CD34(+) cells from the bone marrow and the generation of CD34(+)/KDR + cells in the circulation.

• 出版日期2013-8