An efficient preparation of N-acetyl enamides catalyzed by Ru(II) complexes

作者：Murugan Kaliyappan; Huang Da wei; Chien Yu Ting; Liu Shiuh Tzung^*

来源：Tetrahedron, 2013, 69(1): 268-273.

DOI：10.1016/j.tet.2012.10.027

• Acetylation
• Ruthenium
• Enamide
• Oxime

Reductive acetylation of ketoximes to give the corresponding acyl enamides can be achieved by using 1-3 mol % of [RuCl2(p-cymene)](2) as the catalyst in the presence of KI as the reducing agent in high yields. This procedure has been applied to synthesize N-[1-(1,3-benzodioxol-5-yl)-1-butenyl]acetamide (6), which is the intermediate for the synthesis of DMP 777, an inhibitor of leukocyte elastase.

• 出版日期2013-1-7