Assessment of residual tumours after systemic treatment of metastatic seminoma. F-18-2-Fluoro-2-deoxy-D-glucose positron emission tomography Meta-analysis of diagnostic value

作者：Mueller J^*; Schrader A J; Jentzmik F; Schrader M

来源：Urologe, 2011, 50(3): 322-+.

DOI：10.1007/s00120-010-2469-3

• FDG-PET
• Seminoma
• Testicular cancer
• Residual disease
• Systemic treatment

Background. Meta-analysis evaluating the accuracy and sensitivity of FOG (2-[F-18]-fluoro-2-deoxy-D-glucose) positron emission tomography (PET) to predict viable residual tumours in patients with metastatic seminoma.
Material and methods. Altogether 5 studies with 130 patients were identified. Both FOG PET and the size of the residual lesions on conventional computed tomography (CT; lesions either 5 or > 3 cm) were correlated with the presence or absence of viable residual tumour.
Results. The specificity (92 vs 59%), sensitivity (72 vs 63%), positive (70 vs 28%) and negative (93 vs 86%) predictive value of FDG-PET were superior to data obtained by assessing residual tumour size (either 5 or > 3 cm) applying CT scans alone.
Conclusion. In view of the data currently available, FOG PET seems to be a clinically useful predictor of viable tumour in post-chemotherapy residuals of pure seminoma.

• 出版日期2011-3