摘要
A versatile and practical methodology to access beta amino and beta-hydroxy alpha,alpha-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoto esters. The wide substrate scope highlights the chemoselectivity of the process.
- 出版日期2012-10-19