Indium-Promoted Reformatsky Reaction: A Straightforward Access to beta-Amino and beta-Hydroxy alpha,alpha-Difluoro Carbonyl Compounds

作者:Poisson Thomas*; Belhomme Marie Charlotte; Pannecoucke Xavier
来源:Journal of Organic Chemistry, 2012, 77(20): 9277-9285.
DOI:10.1021/jo301873y

摘要

A versatile and practical methodology to access beta amino and beta-hydroxy alpha,alpha-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines, affording the corresponding and highly valuable gem-difluoto esters. The wide substrate scope highlights the chemoselectivity of the process.

  • 出版日期2012-10-19