Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds

作者：Simonetti Giovanna; D' Auria Felicia Diodata; Mulinacci Nadia; Innocenti Marzia; Antonacci Donato; Angiolella Letizia; Santamaria Anna Rita; Valletta Alessio; Donati Livia; Pasqua Gabriella

来源：Phytotherapy Research, 2017, 31(1): 124-131.

DOI：10.1002/ptr.5739

• dermatophytes
• Malassezia furfur
• Vitaceae
• grape seed extracts
• polymeric flavan-3-ols
• antifungal activity

Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97 mu g/mL for dermatophytes and from 32 to 161 mu g/mL for Malassezia furfur. Dried grape seed extracts analyzed by HPLC/DAD/ESI/MS showed different quali-quantitative compositions in terms of monomeric and polymeric flavan-3-ols. The minimal inhibitory concentrations for Trichophyton mentagrophytes and for M. furfur were inversely correlated with the amount of the polymeric fraction (r = -0.7639 and r = -0.7228, respectively). Differently, the antifungal activity against T. mentagrophytes was not correlated to the content of flavan-3-ol monomers (r = 0.2920) and only weakly correlated for M. furfur (r = -0.53604). These results suggest that extracts rich in polymeric flavan-3-ols, recovered from V. vinifera seeds, could be used for the treatment of skin fungal infections.

• 出版日期2017-1