Mitochondrial DNA polymorphism in the French population

作者：Ivanova R^*; Astrinidis A; Lepage V; Kouvatsi A; Djoulah S; Hors J; Charron D

来源：Biomedicine & Pharmacotherapy, 1999, 53(4): 207-212.

DOI：10.1016/S0753-3322(99)80089-4

• French population
• mtDNA polymorphism
• population genetics
• RFLP

One hundred unrelated individuals of French origin were screened for mtDNA variation as restriction fragment length polymorphisms (RFLPs), with the restriction enzymes HpaI. BamHI. HaeII, MspI, AvaII and HincII. Twenty enzyme morphs were detected, four of which (AvaII-37(Fr), -38(Fr), HincII-18(Fr) and -19(Fr)) are new. Of the: 17 mitotypes detected. five are new and they were named 1-19(Fr), 6-18(Fr) ,100(Fr)-2 (2-1-2-4-1-2). 101(Fr)-2 (2-1-1-1-38(Fr)-2) and 102(Fr)-2 (2-1-1-4-37(Fr)-2). Al new morphs and mitotypes derive from those already known due to a single nucleotide substitution. The French population was compared with other European, Mediterranean and Caucasian populations. Calculation of the genetic distances showed close genetic affinity with European-Mediterranean populations and especially with Calabrians. Majorcans and northern Italians (at negative values).

• 出版日期1999-5