Nephrotic syndrome and acute kidney injury associated with celiac disease. Report of one case

作者：Vega Jorge; Diaz Rienzi; Mendez Gonzalo P; Goecke Helmuth

来源：Revista Medica de Chile, 2013, 141(3): 381-387.

DOI：10.4067/S0034-98872013000300015

• Acute kidney injury
• Nephrotic syndrome
• Shock
• septic

Celiac disease may be associated with other autoimrnune diseases and exceptionally with glomerulopathies and nephrotic syndrome. Associations have been reported with IgA nephropathy, membranoproliferative glomerulonephritis, membranous glomerulopathy and minimal change disease. We report a 63-year-old woman who simultaneously presented with massive nephrotic syndrome (proteinuria 46 g/day) and cachexia due to a malabsorption syndrome secondary to celiac disease. The course of her diseases was complicated with cardiomyopathy due to severe malnutrition, septic shock, acute kidney injury that required dialysis for seven weeks and severe hypertension. A renal biopsy showed a membranoproliferative pattern of injury secondary to a thrombotic microangiopathy and diffuse podocyte damage. Four years latei; the patient was in good general health, the glomerular filtration rate was 30 ml/min/1.73m(2) and there was non-nephrotic proteinuria.

• 出版日期2013-3