Association between GRN rs5848 Polymorphism and Parkinson%26apos;s Disease in Taiwanese Population

作者：Chang Kuo Hsuan; Chen Chiung Mei; Chen Yi Chun; Hsiao Ya Chin; Huang Chin Chang; Kuo Hung Chou; Hsu Hsuan Chu; Lee Chen Guey Jen^*; Wu Yih Ru

来源：PLos One, 2013, 8(1): e54448.

DOI：10.1371/journal.pone.0054448

A single nucleotide polymorphism GRN rs5848 (3%26apos;UTR+78 C %26gt; T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson%26apos;s disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI: 1.77 similar to 2.34, P = 0.021). PD patients demonstrate a higher frequency of T allele (37.2%) than controls (32.2%; odds ratio [OR] = 1.24, 95% CI: 1.04 similar to 1.49, P = 0.017). This susceptibility was particularly observed in female subjects, in which TT genotype had a 2.16-fold increased risk of PD as compared with controls(95% CI: 1.24 similar to 3.78, P = 0.006). The frequency of T allele (39.3%) in female PD patients was higher than in female control subjects (31.1%; OR = 1.43, CI: 1.11 similar to 1.87, P = 0.007). No association was observed between GRN rs5848 and susceptibility in male subjects. These findings show that the GRN rs5848 TT genotype and T allele are risk factors for female Taiwanese patients with PD.

• 出版日期2013-1-16
• 单位长春大学