Acute Lymphoblastic Leukemia After Temozolomide Treatment for Anaplastic Astrocytoma in a Child With a Germ line TP53 Mutation

作者：Momota Hiroyuki^*; Nariata Yoshitaka; Miyakita Yasuji; Hosono Ako; Makimoto Atsushi; Shibui Soichiro

来源：Pediatric Blood and Cancer, 2010, 55(3): 577-579.

DOI：10.1002/pbc.22542

• alkylating agent
• glioma
• p53
• temozolomide
• treatment-related acute leukemia

We present a case of a 12-year-old female with a germline TP53 mutation who presented with anaplastic astrocytoma and subsequent acute lymphoblastic leukemia (ALL) 13 months after starting treatment with temozolomide (TMZ). The patient had no family history of malignancy except her grand father and his siblings. Although alkylating agents such as TMZ are known to induce secondary hematologic malignancy, only several cases of treatment-related acute leukemia have been reported after TMZ-alone chemotherapy for malignant gliomas. We demonstrate a rare case of TMZ-related ALL in a child with glioma possibly associated with a germline TP53 mutation. Pediatr Blood Cancer. 2010;55:577-579.

• 出版日期2010-9