Association between smoking, glycaemia, blood lipoproteins and risk of oral leukoplakia

作者：Granero Fernandez M; Lopez Jornet P^*

来源：Australian Dental Journal, 2017, 62(1): 47-51.

DOI：10.1111/adj.12431

• blood biochemistry
• blood lipid
• leukoplakia
• potentially malignant disorders
• risk factor

BackgroundAmong potentially malignant disorders, oral leukoplakia is the most common in clinical practice. The aim of this study was to assess risk factors associated with oral leukoplakia.
MethodsThis retrospective study included 142 patients diagnosed with oral leukoplakia according to World Health Organization clinical and histopathological criteria and a control group of healthy subjects matched for age and gender. Sociodemographic data were registered for each patient: age, gender, smoking and alcohol consumption. Leukoplakia characteristics were also registered: size, position, clinical form, and presence or absence of dysplasia; all cases of leukoplakia were classified systematically according to clinicopathological stage. Blood lipid component levels of total cholesterol, high-density lipoproteins, low-density lipoproteins and triglycerides were compared between groups.
ResultsSmoking had a significant effect on the risk of leukoplakia (P = 0.01, odds ratio (OR) = 8.33). High glucose levels also increased the probability of leukoplakia (P = 0.03, OR = 6.35), as did low-density lipoproteins (P = 0.049, OR = 5.65). The risk of dysplasia increased among patients presenting the non-homogeneous form of leukoplakia (P = 0.039, OR = 9.06) and among smokers (P = 0.044, OR = 28.33).
ConclusionsSmoking, increased glucose and low-density lipoproteins in the blood are associated with a risk of oral leukoplakia.

• 出版日期2017-3