Adenovirus-36 Seropositivity and Its Relation with Obesity and Metabolic Profile in Children

作者：Parra Rojas Isela^*; Del Moral Hernandez Oscar; Salgado Bernabe Aralia B; Guzman Guzman Iris P; Salgado Goytia Lorenzo; Munoz Valle Jose F

来源：International Journal of Endocrinology, 2013, 2013: 463194.

DOI：10.1155/2013/463194

The human adenovirus 36 (Ad-36) is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. In previous studies, the relationship between Ad-36 seropositivity with obesity was established in adults and children. We evaluated the association of positive antibodies to Ad-36 with obesity and metabolic profile in Mexican children. Seventy -five children with normal-weight and 82 with obesity were studied in this research. All children had a clinic assessment which included weight, height, body circumferences, and skinfold thickness. Laboratory analyzes included triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, and glucose and insulin levels. An enzyme-linked immunosorbent assay (ELISA) was used to determine the antibodies to Ad-36 in the serum samples. The overall Ad-36 seroprevalencewas 73.9%. Ad-36 seropositivity had a higher prevalence in obese children than in normalweight group (58.6 versus 41.4%,.. = 0.007). Ad-36 seropositivitywas associated with obesity (OR = 2.66,.. = 0.01) and high-density lipoprotein <40mg/dL (OR = 2.85,.. = 0.03). The Ad-36 seropositive group had greater risk of 4 metabolic abnormalities compared with those children without none alteration. In summary, Ad-36 seropositivity was associated with obesity and low HDL-c levels in the sample of children studied.

• 出版日期2013