科研之友
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摘要
Calciphylaxis is a rare disorder characterised by microvascular calcification and thrombosis often leading to rapidly progressing ulceration and tissue necrosis. It most commonly affects patients with chronic renal disease. Clinical findings are variable although painful lower limb lesions are characteristic. Some cases can be diagnosed on clinical grounds. However there are useful diagnostic adjuncts. Differential diagnosis includes atherosclerotic vascular disease, pyoderma gangrenosum, vasculitis, necrobiosis lipoidica and warfarin necrosis. Sadly, treatment remains largely supportive. There is a need for heightened interest and targeted research.
- 出版日期2016
