NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS

作者：Howell Mark^*; Green Ryan; Killeen Alexis; Wedderburn Lamar; Picascio Vincent; Rabionet Alejandro; Peng Zhenling; Larina Maya; Xue Bin; Kurgan Lukasz; Uversky Vladimir N

来源：Journal of Biological Systems, 2012, 20(4): 471-511.

DOI：10.1142/S0218339012400086

• Intrinsically disordered protein
• Protein function
• Eukaryotic proteome

Intrinsically disordered proteins or proteins with disordered regions are very common in nature. These proteins have numerous biological functions which are complementary to the biological activities of traditional ordered proteins. A noticeable difference in the amino acid sequences encoding long and short disordered regions was found and this difference was used in the development of length-dependent predictors of intrinsic disorder. In this study, we analyze the scaling of intrinsic disorder in eukaryotic proteins and investigate the presence of length-dependent functions attributed to proteins containing long disordered regions.

• 出版日期2012-12