Patch Testing in Atopic Dermatitis

作者：Nedorost Susan T^*; Babineau Denise

来源：Dermatitis, 2010, 21(5): 251-254.

DOI：10.2310/6620.2010.10036

Background Because atopic dermatitis (AD) patients differ from non AD patients in immunologic responses (they lack beta defensins are more likely to react to protein allergens and are harder to experimentally sensitize to the nonprotein allergens) patch test responses to commercially available patch test series may differ in AD patients
Objective To compare responses to conventional patch tests in AD and non AD patients and to assess the importance of specific allergens in AD
Methods AD patients were strictly defined by history of childhood flexural dermatitis Patients with active disease were patch test readings occured at day 7
Results The overall number of positive patch test results did not differ significantly in AD patients (n = 146) versus non AD patients (n = 1 003) There was no significant increase in nickel sensitivity There was a nonsignificant trend toward an increased number of positive patch test reactions to tixocortol pivalate Compositae mix and propylene glycol in AD patients
Conclusion In AD patients treated with antibiotics and systemic azoles before patch testing the number of positive patch test reactions is almost identical to that of non AD patients Patch test reactions to components of topical medicaments may be more frequent in AD as compared to non AD patients

• 出版日期2010-10