Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging

作者：Yang Min; Fan Quli; Zhang Ruiping; Cheng Kai; Yan Junjie; Pan Donghui; Ma Xiaowei; Lu Alex; Cheng Zhen^*

来源：Biomaterials, 2015, 69: 30-37.

DOI：10.1016/j.biomaterials.2015.08.001

• Apoferritin
• Melanin
• PET
• MRI
• PAI

Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. In this study, the intrinsic photoacoustic signals and the native strong chelating properties with metal ions of melanin nanoparticle (MNP), and transferrin receptor I (TfR1) targeting ability of apoferritin (APF) was employed to construct an efficient nanoplatform (AMF) without tedious assembling process. Smart APF shell significantly in,creased metal ions loading (molar ratio of 1:800, APF/Fe3+) and therefore improved magnetic resonance imaging (MRI) sensitivity. Moreover, synergistic use of Fe3+ and APF contributed to high photoacounstic imaging (PAI) sensitivity. AMF showed excellent bio-stability and presented good in vivo multimodality imaging (PET/MRI/PAI) properties (good tumor uptake, high specificity and high tumor contrast) in HT29 tumor because of its targeting property combined with the enhanced permeability and retention (EPR) effect, making it promising in theranostics and translational nanomedicine.

• 出版日期2015-11
• 单位江苏省原子医学研究所