科研之友
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摘要
Herein, the design of a catalyst that combines lessons learned from peptide biosynthesis, enzymes, and organocatalysts is described. The catalyst features a urea scaffold for carbonyl recognition and elements of nucleophilic catalysis. In the presence of 40 mol % of the organocatalyst, the rate of peptide bond formation is accelerated by 10000 fold over the uncatalyzed reaction between Fmoc-amino acid thioesters and amino acid methyl esters.
- 出版日期2017-10-6
