Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical cancer

作者：Wan Lanling; Ma Kunpeng; Wang Zhiyong; Mou Yingying; Ma Li; Guo Yong^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(2): 2108-2117.

• TNF-alpha
• rs1800629
• cervical cancer

Purpose: The objective of this study was to evaluate the influence of the TNF-alpha rs1800629 polymorphism on the risk of cervical cancer. Methods: A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI). Results: Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-alpha rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians. Conclusions: Our results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-alpha rs1800629 polymorphism.

• 出版日期2015
• 单位潍坊医学院