Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.

作者：Kim Jong Won; Ko Wonmin; Kim Eun; Kim Gil Soo; Hwang Gwi Ja; Son Sangkeun; Jeong Min Hye; Hur Jae Seoun; Oh Hyuncheol; Ko Sung Kyun; Jang Jae Hyuk^*; Ahn Jong Seog^*

来源：Journal of Antibiotics, 2018, 71(8): 753-756.

DOI：10.1038/s41429-018-0058-7

Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin(IL)-1 beta, and IL-6.

• 出版日期2018-8