Dose and elasticity of demand for self-administered cocaine in rats

作者：Kearns David N^*; Silberberg Alan

来源：Behavioural Pharmacology, 2016, 27(2-3): 289-292.

DOI：10.1097/FBP.0000000000000218

• cocaine
• demand
• elasticity
• essential value
• rats
• self-administration

The present experiment tested whether the elasticity of demand for self-administered cocaine in rats is dose-dependent. Subjects lever pressed for three different doses of intravenous cocaine - 0.11, 0.33, and 1.0mg/kg/infusion - on a demand procedure where the number of lever presses required per infusion increased within a session. The main finding was that demand for the 0.11mg/kg dose was more elastic than it was for the two larger doses. There was no difference in demand elasticity between the 0.33 and 1.0mg/kg doses. These results parallel findings previously reported in monkeys. The present study also demonstrated that a within-session procedure can be used to generate reliable demand curves.

• 出版日期2016-4