A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis)

作者：Zao, Chih-Ling^*; Tomanek, Lisa; Cooke, Anthony; Berger, Ron; Yang, Lingyan; Xie, Chen; Chen, Si; Shi, Changjun; Rong, Rong

来源：Journal of General Virology, 2016, 97(11): 3017-3023.

DOI：10.1099/jgv.0.000601

• IMMUNE-DEFICIENCY-SYNDROME
• SEMNOPITHECUS-ENTELLUS
• NUCLEOTIDE-SEQUENCE
• RHESUS-MONKEYS
• MACAQUES
• TRANSMISSION
• PHYLOGENIES
• INFECTION
• FUSCATA
• VIRUS

A new simian retrovirus (SRV) subtype was discovered in China and the USA from Cambodian-origin cynomolgus monkeys. Histopathological examination from necropsied animals showed multifocal lymphoplasmacystic and histocytic inflammation. The complete genome sequences demonstrated that the US virus isolates were nearly identical (99.91-99.93 %) and differed only slightly (99.13-99.16% identical) from the China isolate. Phylogenetic analysis showed that the new virus isolates formed a distinct branch of SRV-1 through -7, and therefore were named this subtype, SRV-8. This SRV-8 variant was also phylogenetically and serologically more closely related to SRV-4 than any other SRV subtype.

• 出版日期2016-11
• 单位西交利物浦大学