Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A

作者：Gold Philip W^*; Pavlatou Maria G; Carlson Paul J; Luckenbaugh David A; Costello Rene; Bonne Omer; Csako Gyorgy; Drevets Wayne C; Remaley Alan T; Charney Dennis S; Neumeister Alexander; Kling Mitchel A

来源：Neuroscience Letters, 2012, 520(1): 1-5.

DOI：10.1016/j.neulet.2012.04.072

• Major depression
• Immunoglobulin IgA
• Proinflammatory state

Patents with major depression have evidence of a proinflammatory state with consistent elevations in acute phase proteins and in the levels of inflammatory mediators such as interleukin-6 and tumor necrosis factor-alpha. We report here a study of the serum levels of immunoglobulin A (IgA) in medication-free patients with major depression in the remitted state (ruMDD). Selective IgA deficiency is the most common form of immunoglobulin abnormality, and is often associated with a higher than expected incidence of proinflammatory and autoimmune phenomena. We measured serum IgG, IgM, and IgA in 28 ruMDD patients and 27 healthy subjects (Ctrl) at 0 (pretreatment), 7, and 24 h following sham depletion and tryptophan (TrpD) depletion conducted at least 8 days apart under balanced, randomized, blinded conditions. Immunoglobulins were measured by automated immunonephelometry. Data were analyzed by repeated measures ANOVA with diagnosis as a fixed effect and drug (TrpD vs. sham), and time as repeated measures factors. Serum IgA was consistently lower in ruMDD patients vs. Ctrl at all time points examined (p < 0.04 for main effect of diagnosis). Serum IgG and IgM levels did not show significant differences by diagnosis. Medication-free patients with major depression in the remitted state have a significant reduction in serum IgA levels measured on multiple occasions. In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state. Published by Elsevier Ireland Ltd.

• 出版日期2012-6-27