Anti-angiogenic activity of Entada africana root

作者:Germano Maria Paola*; Certo Giovanna; D'Angelo Valeria; Sanogo Rokia; Malafronte Nicola; De Tommasi Nunziatina; Rapisarda Antonio
来源:Natural Product Research, 2015, 29(16): 1551-1556.
DOI:10.1080/14786419.2014.987773

摘要

Entada africana roots are used in African traditional medicine for various diseases including inflammation. This application may be mediated through anti-angiogenic effects. Thus, in this study the anti-angiogenic activity of E. africana root extracts (n-hexane, chloroform, chloroform/methanol and methanol) was preliminarily evaluated by the quantitative determination of endogenous alkaline phosphatase in zebrafish embryos. A bioactivity-guided fractionation of chloroform/methanol extract yielded apigenin and robinetin as the main constituents from the most active fractions. In addition, a marked reduction on capillary formation was evidenced in chick chorioallantoic membrane after treatment with the active fractions or isolated compounds. Results obtained in this study suggest that the anti-angiogenic effects of E. africana root may account for its use in inflammatory diseases and other related pathological conditions.

  • 出版日期2015-8-18