Fast and sensitive protein alignment using DIAMOND

作者：Buchfink, Benjamin^*; Xie, Chao; Huson, Daniel H.

来源：Nature Methods, 2015, 12(1): 59-60.

DOI：10.1038/nmeth.3176

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The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.

• 出版日期2015-1
• 单位上海生物信息技术研究中心