Pathways of mechanical unfolding of FnIII(10): Low force intermediates

作者：Caraglio M^*; Imparato A; Pelizzola A

来源：Journal of Chemical Physics, 2010, 133(6): 065101.

DOI：10.1063/1.3464476

• Ising model
• molecular biophysics
• polymers
• stochastic processes

We study the mechanical unfolding pathways of the FnIII(10) domain of fibronectin by means of an Ising-like model, using both constant force and constant velocity protocols. At high forces and high velocities our results are consistent with experiments and previous computational studies. Moreover, the simplicity of the model allows us to probe the biologically relevant low force regime, where we predict the existence of two intermediates with very close elongations. The unfolding pathway is characterized by stochastic transitions between these two intermediates.

• 出版日期2010-8-14