Naive blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity

作者：Slaney Clare Y; Toker Aras; La Flamme Anne; Backstrom B Thomas; Harper Jacquie L^*

来源：Immunology and Cell Biology, 2011, 89(1): 7-13.

DOI：10.1038/icb.2010.110

• blood monocytes
• T-cell suppression
• nitric oxide
• autoimmunity
• EAE

In certain disease context, cells of the monocyte/macrophage lineage are known to exhibit T-cell suppressor function. However, whether naive monocytes are also able to suppress T-cell responses has not been previously investigated. In this study, we have discovered that CD11b(+)Ly6G(-) mononuclear cells in the blood of naive mice are potent suppressors of T-cell proliferation in vitro. The suppression of T-cell proliferation requires cell-cell contact and is partially dependent on nitric oxide production. Following the induction of experimental autoimmune encephalomyelitis in mice, the suppressor function of this blood CD11b(+)Ly6G(-) cell population is impaired. Therefore, blood CD11b(+)Ly6G(-) cells appear to be intrinsically suppressive and may have a key role in maintaining immune homoeostasis. Loss of this suppressive function may contribute to development of autoimmunity. Immunology and Cell Biology (2011) 89, 7-13; doi:10.1038/icb.2010.110; published online 9 November 2010

• 出版日期2011-1
• 单位河北医科大学