Bone Mineral Density Patterns in Vitamin D Deficient African American Men With Sickle Cell Disease

作者：Adams Graves Patricia^*; Daniels Alden B; Womack Catherine R; Freire Amado X

来源：American Journal of the Medical Sciences, 2014, 347(4): 262-266.

DOI：10.1097/MAJ.0b013e3182893377

• Osteopenia
• Sickle cell disease
• Vitamin D
• Osteoporosis
• Densitometry
• Bone mineral density

Objective: To describe bone mineral density (BMD) patterns by densitometry in adult African American (AA) men with sickle cell disease (SCD) who are vitamin D deficient (Vit DD). Inclusion/Exclusion Criteria: All SCD phenotypes were eligible. Those with chronic renal failure or hyperparathyroidism were excluded. Data Collection: Demographics, body mass index and SCD genotype. Laboratory: Albumin, ferritin, calcium, phosphorus, 25-hydroxy vitamin D and intact-parathyroid hormone were obtained. BMD, T and Z scores: T scores at the lumbar spine were used to categorize normal, osteopenia and osteoporosis based on World Health Organization criteria. Statistical Analyses: Mean +/- standard deviation was used to describe continuous data, whereas categorical data were described by counts and percentages. The chi(2) test was used to analyze categorical variables; Student%26apos;s t test or one-way analysis of variance, when appropriate, was used to compare continuous variables. Rates of osteopenia-osteoporosis were determined, and the parameter with 95% confidence interval (CI) of a proportion was constructed. All tests were 2-sided, and a P %26lt;= 0.05 was considered statistically significant. We used StatView Version 5.01 (SAS institute Inc, Cary, NC) for the statistical analysis. Results: Seventy-eight AA men with SCD disease and Vit DD were enrolled in this study. We found that 42% of the men studied had low-BMD (osteopenia or osteoporosis) using T scores at the lumbar spine to establish densitometry strata. The prevalence of osteoporosis was 14%. Conclusions: A large proportion of adult AA men with SCD and Vit DD showed low BMD.

• 出版日期2014-4