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摘要
. Purpose: To evaluate the epithelial healing following photorefractive keratectomy (PRK) with mitomycin C (MMC) 0.02%. Methods: A total of 1520 eyes of 760 patients with myopia with spherical equivalent between -1.5 and -8.0 dioptres underwent PRK during 20042008. The epithelium was removed mechanically, and laser ablation was followed by topical application of MMC (0.02%) for 20 seconds. A therapeutic contact lens (TCL), kept in 4 degrees C, was fitted and worn until complete epithelialization. Antibiotic, steroid and diclofenac drops were instilled during the healing phase. Steroid drops were used for 68 weeks and gradually reduced. The results were compared with a retrospective analysis of 500 myopic eyes which underwent PRK without MMC therapy during 20022004. Results: In 30 MMC treated eyes (2%), epithelial healing was delayed with a stellate defect which healed after 1214 days. Another fifteen eyes (1%) revealed loose midperipheral epithelium and complete epithelialization took 1014 days after scraping. Two of these eyes developed recurrent erosion treated by scraping and TCL. Seven eyes (0.5%) revealed delayed healing with paracentral epithelial plaques which were scraped and complete healing took 1214 days. No final haze was found in the MMC-treated eyes. In comparison, only 0.8% of the eyes which had undergone PRK without MMC revealed epithelial problems. Haze was found in 8% of these eyes. A statistically significant difference was found between the rate of epithelial problems of the two groups (p = 0.002). Conclusions: MMC (0.02%) applied for 20 seconds post-PRK was found to delay epithelial wound healing up to 14 days in 3.5% of patients with myopia compared to 0.8% of PRK eyes without MMC application. Final haze was not found despite delayed epithelialization because of MMC treatment.
- 出版日期2012-5
