Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial

作者：Modaresi Mohammad Reza; Faghihinia Jamal; Kelishadi Roya; Reisi Mohsen^*; Mirlohi Shahrokh; Pajhang Farhad; Sadeghian Majid

来源：Indian Journal of Pediatrics, 2015, 82(9): 794-798.

DOI：10.1007/s12098-015-1729-z

• Acute bronchiolitis
• Nebulized epinephrine
• Nebulized magnesium sulfate

Objective To assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants hospitalized with acute bronchiolitis.
Methods This three-center double masked randomized clinical trial comprised 120 children with moderate to severe bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0.1 ml/kg). The primary outcome was the length of hospital stay. The use of oxygen, temperature, oxygen saturation (SPO2), pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) score were measured in the beginning of the study and during hospitalization.
Results The mean (SD) age of 120 infants was 5.1(+/-2.6) mo and 60% were boys. The length of hospital stay was not different between the two groups (P>0.01). Use of oxygen supplementation, SPO2 and vital signs were similar in the two groups. Improvement in RDAI score was significantly better in infants treated with nebulized magnesium sulfate than in the other group (P 0.01).
Conclusions Thus, in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate is comparable to nebulized epinephrine. However nebulized magnesium sulfate can improve the clinical score so it may have additive effect to reduce symptoms during hospitalization.

• 出版日期2015-9