ACSM4 Polymorphisms Are Associated With Rapid AIDS Progression in HIV-Infected Patients

作者：McLeod Katherine E^*; Omar Tanvier; Tiemessen Caroline T; Tshabangu Nkeko; Martinson Neil A

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2014, 65(1): E29-+.

DOI：10.1097/QAI.0b013e3182a990e2

• NEMP
• ACSM4
• single nucleotide polymorphism
• rapid progressors
• LTNPs

Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.

• 出版日期2014-1-1