A facile synthesis of glyco 3-nitrochromane hybrid pyrrolidinyl spiro heterocycles via [3+2] cycloaddition of azomethine ylides

作者：Rao J Naga Siva; Raghunathan R^*

来源：Tetrahedron Letters, 2015, 56(17): 2276-2279.

DOI：10.1016/j.tetlet.2015.03.069

• 1,3-Dipolar cycloaddition
• Azomethine ylide
• Carbohydrates
• Pyrrolidinyl-spirooxindoles
• Benzopyranopyrrolidines

A series of diverse glyco 3-nitrochromane hybrid pyrrolidinyl spiro heterocycles have been synthesized by [3+2] cycloaddition reaction of azomethine ylides generated in situ by the condensation of diketones (isatin or acenaphthenequinone)/indenoquinoxalinone and secondary a-amino acids with glyco 3-nitrochromenes as dipolarophiles. This method is simple and provides biologically interesting products. The regio- and stereochemical outcome of the cycloaddition reaction is ascertained by X-ray crystallographic analysis.

• 出版日期2015-4-22