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摘要
Background: Currently, early changes of tumor vasculature after angiogenesis inhibition can only be evaluated by histopathology, a method not suitable in a clinical setting. %26lt;br%26gt;Purpose: To quantify effects of different angiogenesis inhibitors on the microvasculature of orthotopically implanted pancreatic cancers by contrast-enhanced magnetic resonance imaging (MRI) in order to establish a non-invasive technique for monitoring antiangiogenic cancer treatment. %26lt;br%26gt;Material and Methods: DSL-6A/C1 pancreatic cancers were implanted in the pancreas of 109 Lewis rats. Three weeks later, antiangiogenic treatment was initiated by administration of Bevacizumab (n = 38) or Suramin (n = 27) while the control group (n = 44) remained untreated. Dynamic MRI was performed 24 h, 1 week, and 4 weeks after treatment initiation. Fractional tumor plasma volume (fPV, %) and vascular permeability (K-PS, mL/min/100 cc) were calculated based on the MRI data by using a pharmacokinetic model. %26lt;br%26gt;Results: Twenty-four hours after the initial dose, a significant decline in K-PS was observed in the Bevacizumab group compared to the control and Suramin group (0.002 +/- 0.008; 0.057 +/- 0.046 and 0.064 +/- 0.062 (mean +/- SD); P %26lt; 0.05). At 1 week, fPV was significantly smaller in Bevacizumab and Suramin treated tumors compared to control tumors (6.25 +/- 2.74, 7.47 +/- 3.44, and 15.10 +/- 9.97, respectively; P %26lt; 0.05). Differences in tumor volumes were first observed after 4 weeks of treatment with significantly larger control tumors (4380.3 +/- 1590.6 vs. 869.6 +/- 717.2 and 1676.5 +/- 2524.1 mm 3; P %26lt; 0.05). %26lt;br%26gt;Conclusion: Dynamic MRI can quantify antiangiogenic effects on tumor microvasculature before changes in tumor volumes are detectable. Thus, this technique is a reasonable addition to morphological MRI and may be applied as an alternative to histopathology.
- 出版日期2014-3
